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Article

Hereditary lung cancer syndrome targets never smokers with germline EGFR gene T790M mutations.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2014

Gazdar Adi, Robinson Linda, Oliver Dwight, Xing Chao, Travis William D, Soh Junichi, Toyooka Shinichi, Watumull Lori, Xie Yang, Kernstine Kemp, Schiller Joan H

Abstract excerpt

INTRODUCTION: Hereditary lung cancer syndromes are rare, and T790M germline mutations of the epidermal growth factor receptor (EGFR) gene predispose to the development of lung cancer. The goal of this study was to determine the clinical features and smoking status of lung cancer cases and unaffected family members with this germline mutation and to estimate its incidence and penetrance. METHODS: We studied a...

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Identifiers

PMID: 24736066
DOI: 10.1097/JTO.0000000000000130
PMCID: PMC4509739

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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