Article
Family Matters: Germline Testing in Thoracic Cancers.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting - 1 May 2023
Hathaway Feighanne, Martins Renato, Sorscher Steven, Bzura Aleksandra, Dudbridge Frank, Fennell Dean A
Abstract excerpt
Most thoracic cancers arise via a series of stepwise somatic alterations driven by a well-defined carcinogen (ie, tobacco or asbestos for lung cancer and mesothelioma, respectively). A small proportion can emerge on a background of pathogenic germline variants (PGVs), which have the property of heritability. In general, PGVs may be initially suspected on the basis of the presence of specific clinical features....
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