Germline EGFR T790M mutation and lung cancer risk.

doi:10.1126/science.aec0473

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Article

Germline EGFR T790M mutation and lung cancer risk.

Science (New York, N.Y.) - 17 Sept 2026

LoPiccolo Jaclyn, Micheletti Steven, Shi Jing, Wang Wei, Saini Shubham, Lin Keng-Han, Xu Wanwan, Fontanillas Pierre, Koeller Diane R, Yatzus Helen, Williamson Victoria G, Avila Jose A, Liautaud Raphael B, Fields Noah D, Harper Allison, Kotait Virginia, Izzo Ericka, Ciupek Andrew, Granville Courtney A, Collins Ryan L, Garber Judy E, Christiani David C, Aslibekyan Stella, Granka Julie M, Gusev Alexander, Jänne Pasi A

Abstract excerpt

Most lung cancers are tobacco related, with genetic factors influencing smoking behavior identified through genome-wide association studies. However, inherited risk in familial and non-smoking-related lung cancers, including risk in carriers of EGFR T790M, remains poorly understood. Here, in more than 3.3 million individuals, the EGFR T790M germline variant is significantly associated with lung cancer risk, with...

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Topics

Humans
ErbB Receptors
Founder Effect
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Germ-Line Mutation

Lung Neoplasms

Smoking

United States

Male

Female

European People

African People

Source

Open in PubMed

Identifiers

PMID: 42752144
DOI: 10.1126/science.aec0473

Genes

EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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