Family history enrichment in Non-Small cell Lung Cancer: A cross-sectional - prospective study to inform referral for germline testing.

doi:10.1016/j.lungcan.2026.109346

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Family history enrichment in Non-Small cell Lung Cancer: A cross-sectional - prospective study to inform referral for germline testing.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2026

Citarella Fabrizio, Venanzi Francesco M, Di Giovanni Giulia, Takada Kazuki, Cascetta Priscilla, Crucitti Pierfilippo, Lintas Carla, Fiorenti Mattero, Mingo Emanuele C, La Cava Giulia, Russano Marco, Pantano Francesco, Vincenzi Bruno, Tonini Giuseppe, Vavalà Tiziana, Milanesi Enrica, Oresti Sara, Crinò Lucio, Delmonte Angelo, Ferrara Roberto, Di Maio Massimo, Gurrieri Fiorella, Cortellini Alessio

Abstract excerpt

BACKGROUND: Family history of cancer (FHC) is a recognized proxy of inherited cancer susceptibility. In NSCLC, however, the clinical relevance of FHC remains poorly defined, and standardized approaches to identify patients enriched for pathogenic germline variants (PGVs) are lacking. METHODS: FAHIC-Lung (NCT06196424) is a multicenter, cross-sectional/prospective observational study conducted in Italy. Consecutive...

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PMID: 41764946
DOI: 10.1016/j.lungcan.2026.109346

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