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T cell receptor sequencing of early-stage breast cancer tumors identifies altered clonal structure of the T cell repertoire

14 Nov 2017

Abstract excerpt

Tumor-infiltrating T cells play an important role in many cancers, and can improve prognosis and yield therapeutic targets. We characterized T cells infiltrating both breast cancer tumors and the surrounding normal breast tissue to identify T cells specific to each, as well as their abundance in peripheral blood. Using immune profiling of the T cell beta-chain repertoire in 16 patients with early-stage breast...

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PMID: 29138313
DOI: 10.1073/pnas.1713863114

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