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Article

Whole-genome sequencing of phenotypically distinct inflammatory breast cancers reveals similar genomic alterations to non-inflammatory breast cancers.

Genome medicine - 26 Apr 2021

Li Xiaotong, Kumar Sushant, Harmanci Arif, Li Shantao, Kitchen Robert R, Zhang Yan, Wali Vikram B, Reddy Sangeetha M, Woodward Wendy A, Reuben James M, Rozowsky Joel, Hatzis Christos, Ueno Naoto T, Krishnamurthy Savitri, Pusztai Lajos, Gerstein Mark

Abstract excerpt

BACKGROUND: Inflammatory breast cancer (IBC) has a highly invasive and metastatic phenotype. However, little is known about its genetic drivers. To address this, we report the largest cohort of whole-genome sequencing (WGS) of IBC cases. METHODS: We performed WGS of 20 IBC samples and paired normal blood DNA to identify genomic alterations. For comparison, we used 23 matched non-IBC samples from the Cancer Genome...

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Identifiers

PMID: 33902690
DOI: 10.1186/s13073-021-00879-x
PMCID: PMC8077918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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