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Article

A common variant that alters SUN1 degradation associates with hepatic steatosis and metabolic traits in multiple cohorts.

Journal of hepatology - 1 Nov 2023

Upadhyay Kapil K, Du Xiaomeng, Chen Yanhua, Buscher Brandon, Chen Vincent L, Oliveri Antonino, Zhao Raymond, Speliotes Elizabeth K, Brady Graham F

Abstract excerpt

BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD), and its progressive form steatohepatitis (NASH), represent a genetically and phenotypically diverse entity for which there is no approved therapy, making it imperative to define the spectrum of pathways contributing to its pathogenesis. Rare variants in genes encoding nuclear envelope proteins cause lipodystrophy with early-onset NAFLD/NASH; we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37567366
DOI: 10.1016/j.jhep.2023.07.036
PMCID: PMC10618955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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