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Article

Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.

Hepatology (Baltimore, Md.) - 1 May 2018

Brady Graham F, Kwan Raymond, Ulintz Peter J, Nguyen Phirum, Bassirian Shirin, Basrur Venkatesha, Nesvizhskii Alexey I, Loomba Rohit, Omary M Bishr

Abstract excerpt

Nonalcoholic fatty liver disease (NAFLD) is becoming the major chronic liver disease in many countries. Its pathogenesis is multifactorial, but twin and familial studies indicate significant heritability, which is not fully explained by currently known genetic susceptibility loci. Notably, mutations in genes encoding nuclear lamina proteins, including lamins, cause lipodystrophy syndromes that include NAFLD. We...

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Source

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Identifiers

PMID: 28902428
DOI: 10.1002/hep.29522
PMCID: PMC5849478

Genes

TMPO
PNPLA3
SQSTM1
ZMPSTE24

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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