A minority of somatically mutated genes in pre-existing fatty liver disease have prognostic importance in the development of NAFLD.

Abstract excerpt

BACKGROUND: Understanding the genetics of liver disease has the potential to facilitate clinical risk stratification. We recently identified acquired somatic mutations in six genes and one lncRNA in pre-existing fatty liver disease. We hypothesised that germline variation in these genes might be associated with the risk of developing steatosis and contribute to the prediction of disease severity. METHODS:...

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