Article

A common variant that alters SUN1 degradation associates with hepatic steatosis and metabolic traits in multiple cohorts

2022-10-21

Abstract excerpt

Nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) represent a genetically and phenotypically diverse entity with no approved therapy, making it imperative to define the spectrum of pathways contributing to its pathogenesis. Rare variants in genes encoding nuclear envelope proteins cause lipodystrophy that includes early-onset NASH; we hypothesized that common variants in nuclear envelope-rela...

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Identifiers and source

Literature Corpus work: 00344eea-67bd-5b37-a7b6-1d5ad7597ff1
DOI: 10.1101/2022.10.19.22280653

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