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Splice variant rs72613567 prevents worst histologic outcomes in patients with nonalcoholic fatty liver disease

15 Oct 2018

Abstract excerpt

Hydroxysteroid 17-#x03B2; dehydrogenase 13 (HSD17B13) is a lipid droplet-associated protein; its gene-encoding variants affect the chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD). To estimate the effect of rs72613567, a splice variant with an adenine insertion (A-INS), on NAFLD susceptibility and severity, we performed a case-control study with 609 individuals. We investigated the...

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PMID: 30323112
DOI: 10.1194/jlr.p089953

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