Article

The inner nuclear membrane protein SUN1 regulates cullin-3 neddylation to maintain insulin signaling

2026-04-20

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease and strongly linked to obesity and insulin resistance. We previously reported that the common nuclear envelope variant rs6461378 (g.842031C>T; SUN1 H118Y) associated with MASLD and related traits including insulin resistance. To gain insight into how wild-type (WT) and H118Y SUN1 might differentially impac...

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Literature Corpus work: 5ab1f5dc-14ba-5f54-9aac-a142d907c9d8
DOI: 10.64898/2026.04.16.718478

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