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Independent and combined effects of methamphetamine use disorders and APOEε4 allele on cognitive performance and brain morphometry.

Addiction (Abingdon, England) - 1 Dec 2023

Wang Hannah A, Liang Hua-Jun, Ernst Thomas M, Nakama Helenna, Cunningham Eric, Chang Linda

Abstract excerpt

AIMS: Prior studies showed that methamphetamine (METH) users had greater than normal age-related brain atrophy; whether having the apolipoprotein E (APOE)-ε4 allele may be a contributory factor has not been evaluated. We aimed to determine the independent and combined effects of chronic heavy METH use and having at least one copy of the APOE-ε4 allele (APOE-ε4+) on brain morphometry and cognition, especially in...

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Identifiers

PMID: 37563863
DOI: 10.1111/add.16309
PMCID: PMC10840926

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