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Article

CYP2D6 genotype may moderate measures of brain structure in methamphetamine users.

Addiction biology - 1 May 2021

Dean Andy C, Nurmi Erika L, Morales Angelica M, Cho Arthur K, Seaman Lauren C, London Edythe D

Abstract excerpt

Chronic methamphetamine use is linked to abnormalities in brain structure, which may reflect neurotoxicity related to metabolism of the drug. As the cytochrome P450 2D6 (CYP2D6) enzyme is central to the metabolism of methamphetamine, genotypic variation in its activity may moderate effects of methamphetamine on brain structure and function. This study explored the relationship between CYP2D6 genotype and measures...

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Share to Amphetamine-Related Disorders
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32767519
DOI: 10.1111/adb.12950
PMCID: PMC7865018

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