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Article

Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease.

PloS one - 1 Jan 2013

Hostage Christopher A, Roy Choudhury Kingshuk, Doraiswamy Pudugramam Murali, Petrella Jeffrey R

Abstract excerpt

OBJECTIVE: To investigate whether there is a specific dose-dependent effect of the Apolipoprotein E (APOE) ε4 and ε2 alleles on hippocampal volume, across the cognitive spectrum, from normal aging to Alzheimer's Disease (AD). MATERIALS AND METHODS: We analyzed MR and genetic data on 662 patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database-198 cognitively normal controls (CN), 321...

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Identifiers

PMID: 23405083
DOI: 10.1371/journal.pone.0054483
PMCID: PMC3566140

Genes

APOE

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