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Article

The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study.

Dementia and geriatric cognitive disorders - 1 Jan 2006

Pennanen Corina, Testa Cristina, Boccardi Marina, Laakso Mikko P, Hallikainen Merja, Helkala Eeva-Liisa, Hänninen Tuomo, Kivipelto Miia, Könönen Mervi, Nissinen Aulikki, Tervo Susanna, Vanhanen Matti, Vanninen Ritva, Frisoni Giovani B, Soininen Hilkka

Abstract excerpt

We investigated the effect of apolipoprotein E (ApoE) on the whole brain in 51 individuals with mild cognitive impairment using voxel-based morphometry. Between cases heterozygous for the ApoE epsilon4 (n = 15) and those who were ApoE epsilon4 noncarriers (n = 28), only the right parahippocampal gyrus, with the entorhinal cortex included, reached the level of statistical significance. In cases homozygous for the...

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Identifiers

PMID: 16682795
DOI: 10.1159/000093263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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