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Article

TMEM106B aggregation in neurodegenerative diseases: linking genetics to function.

Molecular neurodegeneration - 10 Aug 2023

Jiao Hai-Shan, Yuan Peng, Yu Jin-Tai

Abstract excerpt

BACKGROUND: Mutations of the gene TMEM106B are risk factors for diverse neurodegenerative diseases. Previous understanding of the underlying mechanism focused on the impairment of lysosome biogenesis caused by TMEM106B loss-of-function. However, mutations in TMEM106B increase its expression level, thus the molecular process linking these mutations to the apparent disruption in TMEM106B function remains...

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Identifiers

PMID: 37563705
DOI: 10.1186/s13024-023-00644-1
PMCID: PMC10413548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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