TMEM106B aggregation in neurodegenerative diseases: linking genetics to function.

Abstract excerpt

BACKGROUND: Mutations of the gene TMEM106B are risk factors for diverse neurodegenerative diseases. Previous understanding of the underlying mechanism focused on the impairment of lysosome biogenesis caused by TMEM106B loss-of-function. However, mutations in TMEM106B increase its expression level, thus the molecular process linking these mutations to the apparent disruption in TMEM106B function remains...

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• Alzheimer's disease research and treatments
• Amyotrophic Lateral Sclerosis Research
• Lysosomal Storage Disorders Research
• Membrane Proteins
• Mutation