Article

Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice

2023-11-15

Abstract excerpt

TMEM106B , a gene encoding a lysosome membrane protein, is tightly associated with brain aging, hypomyelinating leukodystrophy, and multiple neurodegenerative diseases, including frontotemporal lobar degeneration with TDP-43 aggregates (FTLD-TDP). Recently, TMEM106B polymorphisms have been associated with tauopathy in chronic traumatic encephalopathy (CTE) and FTLD-TDP patients. However, how TMEM106B influences T...

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Literature Corpus work: eebe6439-52e0-530b-8eff-a351c78475b8
DOI: 10.1101/2023.11.11.566707

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