Article

Gene–Dose–Dependent Reduction <i>Fshr</i> Expression Improves Spatial Memory Deficits in Alzheimer’s Mice

2024-02-21

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a major progressive neurodegenerative disorder of the aging population. High post–menopausal levels of the pituitary gonadotropin follicle–stimulating hormone (FSH) are strongly associated with the onset of AD, and we have shown recently that FSH directly activates the hippocampal Fshr to drive AD–like pathology and memory loss in mice. To establish a role for FSH in...

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Literature Corpus work: 956bfd5e-1007-5813-ae6e-73274fa35f05
DOI: 10.1101/2024.02.16.580761

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