Article
Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice.
Physiology & behavior - 1 Apr 2001
Kinney B A, Coschigano K T, Kopchick J J, Steger R W, Bartke A
Abstract excerpt
Although the role of growth hormone (GH) in aging is controversial, the recent production of GH-R-KO mice may provide a means for elucidating its importance. Using the inhibitory avoidance learning task as a measure of cognitive aging, the present study compared learning and retention in young and old GH-R-KO mice and their normal siblings. Results for the old normal animals agreed with the current literature, in...
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