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Article

Observing inhibition of the SARS-CoV-2 helicase at single-nucleotide resolution

10 Aug 2023

Abstract excerpt

The genome of SARS-CoV-2 encodes for a helicase (nsp13) that is essential for viral replication and highly conserved across related viruses, making it an attractive antiviral target. Here we use nanopore tweezers, a high-resolution single-molecule technique, to gain detailed insight into how nsp13 turns ATP-hydrolysis into directed motion along nucleic acid strands. We measured nsp13 both as it translocates along...

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PMID: 37560916
DOI: 10.1093/nar/gkad660

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