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Biochemical Characterization of Middle East Respiratory Syndrome Coronavirus Helicase

8 Sept 2016

Abstract excerpt

Middle East respiratory syndrome coronavirus (MERS-CoV) helicase is a superfamily 1 helicase containing seven conserved motifs. We have cloned, expressed, and purified a Strep-fused recombinant MERS-CoV nonstructural protein 13 (M-nsp13) helicase. Characterization of its biochemical properties showed that it unwound DNA and RNA similarly to severe acute respiratory syndrome CoV nsp13 (S-nsp13) helicase. We showed...

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PMID: 27631026
DOI: 10.1128/msphere.00235-16

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