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Article

Altering the speed of a DNA packaging motor from bacteriophage T4.

Nucleic acids research - 2 Nov 2017

Lin Siying, Alam Tanfis I, Kottadiel Vishal I, VanGessel Carl J, Tang Wei-Chun, Chemla Yann R, Rao Venigalla B

Abstract excerpt

The speed at which a molecular motor operates is critically important for the survival of a virus or an organism but very little is known about the underlying mechanisms. Tailed bacteriophage T4 employs one of the fastest and most powerful packaging motors, a pentamer of gp17 that translocates DNA at a rate of up to ∼2000-bp/s. We hypothesize, guided by structural and genetic analyses, that a unique hydrophobic...

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Identifiers

PMID: 28981683
DOI: 10.1093/nar/gkx809
PMCID: PMC5737356

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Source receipt: pubmed, retrieved 7 Sept 2026.

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