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Article

Multi-omic underpinnings of epigenetic aging and human longevity.

Nature communications - 19 Apr 2023

Mavromatis Lucas A, Rosoff Daniel B, Bell Andrew S, Jung Jeesun, Wagner Josephin, Lohoff Falk W

Abstract excerpt

Biological aging is accompanied by increasing morbidity, mortality, and healthcare costs; however, its molecular mechanisms are poorly understood. Here, we use multi-omic methods to integrate genomic, transcriptomic, and metabolomic data and identify biological associations with four measures of epigenetic age acceleration and a human longevity phenotype comprising healthspan, lifespan, and exceptional longevity...

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Identifiers

PMID: 37076473
DOI: 10.1038/s41467-023-37729-w
PMCID: PMC10115892

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