Article

The Evolutionary Impact of Childhood Cancer on the Human Gene Pool

2023-03-10

Abstract excerpt

<title>Abstract</title> <p>Germline pathogenic variants associated with increased childhood mortality must be subject to natural selection. Here, we analyzed publically available germline genetic metadata from 141,456 adults [gnomAD; 125,748 whole exome sequences (WES) and 15,708 whole genome sequences (WGS)] and 4,810 children with cancer [11 studies; 1,319 WES, 1,950 WGS, and 1,541 gene panel]. We found that pe...

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Literature Corpus work: 9cb35383-536e-58ea-90bd-7eb073247591
DOI: 10.21203/rs.3.rs-2658025/v1

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