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Article

Prefrontal cortex-specific Dcc deletion induces schizophrenia-related behavioral phenotypes and fail to be rescued by olanzapine treatment.

European journal of pharmacology - 5 Oct 2023

Sun Jing, Cong Qijie, Sun Tingkai, Xi Siyu, Liu Yunxi, Zeng Rongsen, Wang Jia, Zhang Weining, Gao Jing, Qian Jinjun, Qin Shengying

Abstract excerpt

Multiple genome studies have discovered that variation in deleted in colorectal carcinoma (Dcc) at transcription and translation level were associated with the occurrences of psychiatric disorders. Yet, little is known about the function of Dcc in schizophrenia (SCZ)-related behavioral abnormalities and the efficacy of antipsychotic drugs in vivo. Here, we used an animal model of prefrontal cortex-specific...

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Identifiers

PMID: 37541362
DOI: 10.1016/j.ejphar.2023.175940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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