Article
Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients.
Scientific reports - 1 Jan 2011
Hatayama Minoru, Ishiguro Akira, Iwayama Yoshimi, Takashima Noriko, Sakoori Kazuto, Toyota Tomoko, Nozaki Yayoi, Odaka Yuri S, Yamada Kazuyuki, Yoshikawa Takeo, Aruga Jun
Abstract excerpt
ZIC2 is a causal gene for holoprosencephaly and encodes a zinc-finger-type transcriptional regulator. We characterized Zic2(kd/+) mice with a moderate (40%) reduction in Zic2 expression. Zic2(kd/+) mice showed increased locomotor activity in novel environments, cognitive and sensorimotor gating dysfunctions, and social behavioral abnormalities. Zic2(kd/+) brain involved enlargement of the lateral ventricle,...
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