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Article

Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants.

Human molecular genetics - 15 Oct 2008

Sakae Nobutaka, Yamasaki Nobuyuki, Kitaichi Kiyoyuki, Fukuda Takaichi, Yamada Mitsunori, Yoshikawa Hiroo, Hiranita Takato, Tatsumi Yoshiki, Kira Jun-ichi, Yamamoto Tsuneyuki, Miyakawa Tsuyoshi, Nakayama Keiichi I

Abstract excerpt

FEZ1 (fasciculation and elongation protein zeta 1), a mammalian ortholog of Caenorhabditis elegans UNC-76, interacts with DISC1 (disrupted in schizophrenia 1), a schizophrenia susceptibility gene product, and polymorphisms of human FEZ1 have been associated with schizophrenia. We have now investigated the role of FEZ1 in brain development and the pathogenesis of schizophrenia by generating mice that lack Fez1....

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Source

Identifiers

PMID: 18647754
DOI: 10.1093/hmg/ddn215

Genes

FEZ1
DISC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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