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Article

Somatic mutations in facial skin from countries of contrasting skin cancer risk.

Nature genetics - 1 Sept 2023

King Charlotte, Fowler Joanna C, Abnizova Irina, Sood Roshan K, Hall Michael W J, Szeverényi Ildikó, Tham Muly, Huang Jingxiang, Young Stephanie Ming, Hall Benjamin A, Birgitte Lane E, Jones Philip H

Abstract excerpt

The incidence of keratinocyte cancer (basal cell and squamous cell carcinomas of the skin) is 17-fold lower in Singapore than the UK1-3, despite Singapore receiving 2-3 times more ultraviolet (UV) radiation4,5. Aging skin contains somatic mutant clones from which such cancers develop6,7. We hypothesized that differences in keratinocyte cancer incidence may be reflected in the normal skin mutational landscape....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37537257
DOI: 10.1038/s41588-023-01468-x
PMCID: PMC10484783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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