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Article

Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma.

Nature communications - 27 Nov 2025

Tandukar Bishal, Deivendran Delahny, Chen Limin, Bandari Aravind K, Cruz-Pacheco Noel, Sharma Harsh, Wang Meng, Xu Albert, Chen Daniel B, George Christopher D, Marty Annika L, Cho Raymond J, Cheng Jeffrey B, Saylor Drew, Gerami Pedram, Yeh Iwei, Arron Sarah T, Bastian Boris C, Shain A Hunter

Abstract excerpt

Cutaneous squamous cell carcinomas (cSCCs) arise from keratinocytes in the skin, but the molecular changes driving this transformation remain unclear. To better understand this process, we perform multi-omic profiling of keratinocytes, actinic keratoses, and cSCCs. Single-cell mutational analyses reveal that most keratinocytes have remarkably low mutation burdens; however, keratinocytes with TP53 or NOTCH1...

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Share to Cyclin-Dependent Kinase Inhibitor p16
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41309580
DOI: 10.1038/s41467-025-65687-y
PMCID: PMC12660313

Genes

ARID2
CDKN2A
NOTCH1
TERT
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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