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The Mutational and Microenvironmental Landscape of Cutaneous Squamous Cell Carcinoma: A Review

21 Aug 2024

Abstract excerpt

Cutaneous squamous cell carcinoma (cSCC) manifests through the complex interactions of UV-induced DNA damage, genetic mutations, and alterations in the tumor microenvironment. A high mutational burden is present in cSCC, as well as both cSCC precursors and normal skin, making driver genes difficult to differentiate. Despite this, several key driver genes have been identified, including TP53, the NOTCH family,...

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PMID: 39199674
DOI: 10.3390/cancers16162904

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