Article
The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration.
Science advances - 15 Apr 2022
Mastrogiovanni Marta, Vargas Pablo, Rose Thierry, Cuche Céline, Esposito Elric, Juzans Marie, Laude Hélène, Schneider Amandine, Bernard Mathilde, Goyard Sophie, Renaudat Charlotte, Ungeheuer Marie-Noëlle, Delon Jérôme, Alcover Andrés, Di Bartolo Vincenzo
Abstract excerpt
Adenomatous polyposis coli (APC) is a tumor suppressor whose mutations underlie familial adenomatous polyposis (FAP) and colorectal cancer. Although its role in intestinal epithelial cells is well characterized, APC importance in T cell biology is ill defined. APC regulates cytoskeleton organization, cell polarity, and migration in various cell types. Here, we address whether APC plays a role in T lymphocyte...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.