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TRMT61B rs4563180 G>C variant reduces hepatoblastoma risk: a case-control study of seven medical centers.

Aging - 1 Aug 2023

Zeng Dingyuan, Zhu Jinhong, Li Jingjing, Liao Fan, Yang Zhonghua, Li Yong, Zhang Jiao, Cheng Jiwen, Li Suhong, Li Li, He Jing

Abstract excerpt

N1-methyladenosine (m1A) is an essential chemical modification of RNA. Dysregulation of RNA m1A modification and m1A-related regulators is detected in several adult tumors. Whether aberrant RNA m1A modification is involved in hepatoblast carcinogenesis has not been reported. tRNA methyltransferase 61B (TRMT61B) is responsible for mitochondrial RNA m1A modification. Some evidence has shown that genetic variants of...

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PMID: 37531210
DOI: 10.18632/aging.204926
PMCID: PMC10457066

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