Article
UGT1A1 sequence variants associated with risk of adult hyperbilirubinemia: a quantitative analysis.
Gene - 15 Nov 2014
Chen Zhiwei, Su Dazhi, Ai Luoyan, Jiang Xiaoke, Wu Changwei, Xu Qingqing, Wang Xiaohan, Fan Zhuping
Abstract excerpt
BACKGROUNDS AND AIMS: UDP-glucuronosyltransferase 1 A1 (UGT1A1) is an enzyme that transforms small lipophilic molecules into water-soluble and excretable metabolites. UGT1A1 polymorphisms contribute to hyperbilirubinemia. This study quantitatively associated UGT1A1 variants in patients with hyperbilirubinemia and healthy subjects. METHODS: A total of 104 individuals with hyperbilirubinemia and 105 healthy...
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