Targeting protein homeostasis in sporadic inclusion body myositis.

doi:10.1126/scitranslmed.aad4583

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Article

Targeting protein homeostasis in sporadic inclusion body myositis.

Science translational medicine - 23 Mar 2016

Ahmed Mhoriam, Machado Pedro M, Miller Adrian, Spicer Charlotte, Herbelin Laura, He Jianghua, Noel Janelle, Wang Yunxia, McVey April L, Pasnoor Mamatha, Gallagher Philip, Statland Jeffrey, Lu Ching-Hua, Kalmar Bernadett, Brady Stefen, Sethi Huma, Samandouras George, Parton Matt, Holton Janice L, Weston Anne, Collinson Lucy, Taylor J Paul, Schiavo Giampietro, Hanna Michael G, Barohn Richard J, Dimachkie Mazen M, Greensmith Linda

Abstract excerpt

Sporadic inclusion body myositis (sIBM) is the commonest severe myopathy in patients more than 50 years of age. Previous therapeutic trials have targeted the inflammatory features of sIBM but all have failed. Because protein dyshomeostasis may also play a role in sIBM, we tested the effects of targeting this feature of the disease. Using rat myoblast cultures, we found that up-regulation of the heat shock...

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PMID: 27009270
DOI: 10.1126/scitranslmed.aad4583
PMCID: PMC5043094

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