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Article

Massively parallel screen uncovers many rare 3' UTR variants regulating mRNA abundance of cancer driver genes.

Nature communications - 18 Apr 2024

Fu Ting, Amoah Kofi, Chan Tracey W, Bahn Jae Hoon, Lee Jae-Hyung, Terrazas Sari, Chong Rockie, Kosuri Sriram, Xiao Xinshu

Abstract excerpt

Understanding the function of rare non-coding variants represents a significant challenge. Using MapUTR, a screening method, we studied the function of rare 3' UTR variants affecting mRNA abundance post-transcriptionally. Among 17,301 rare gnomAD variants, an average of 24.5% were functional, with 70% in cancer-related genes, many in critical cancer pathways. This observation motivated an interrogation of 11,929...

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PMID: 38637555
DOI: 10.1038/s41467-024-46795-7
PMCID: PMC11026479

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