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Article

Single-Nucleotide Polymorphisms in Base-Excision Repair-Related Genes Involved in the Risk of an Occurrence of Non-Alcoholic Fatty Liver Disease.

International journal of molecular sciences - 11 Jul 2023

Ziółkowska Sylwia, Kosmalski Marcin, Kołodziej Łukasz, Jabłkowska Aleksandra, Szemraj Janusz Zbigniew, Pietras Tadeusz, Jabłkowski Maciej, Czarny Piotr Lech

Abstract excerpt

Oxidative stress is one of the pillars crucial in the development of a non-alcoholic fatty liver disease (NAFLD) and may cause DNA damage. Since the main pathway responsible for the repair of oxidative DNA damage is the base-excision repair (BER) pathway, we examined the relationship between the presence of different genetic variants of BER-associated genes and the risk of NAFLD. The study evaluates seven single...

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Identifiers

PMID: 37511066
DOI: 10.3390/ijms241411307
PMCID: PMC10379279

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