Article
Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population.
World journal of gastroenterology - 28 Mar 2020
Yang Wan-Na, Pang Li-Li, Zhou Ji-Yuan, Qiu Yuan-Wang, Miao Liang, Wang Shou-Yun, Liu Xiang-Zhong, Tan Kang-An, Shi Wan-Wan, Wang Gui-Qiang, Hou Feng-Qin
Abstract excerpt
BACKGROUND: Polygonum multiflorum is one of the leading causes of herb-induced liver injury in China. HLA-B*35:01 is reported to be a potential biomarker of Polygonum multiflorum-induced liver injury (PM-DILI). However, little is known about the relationship between single-nucleotide polymorphisms (SNPs) and PM-DILI. AIM: To identify SNPs that indicate susceptibility to PM-DILI. METHODS: We conducted a systematic...
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