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Article

The Relationship Between Single-Nucleotide Polymorphisms, the Expression of DNA Damage Response Genes, and Hepatocellular Carcinoma in a Polish Population.

DNA and cell biology - 1 Aug 2017

Krupa Renata, Czarny Piotr, Wigner Paulina, Wozny Joanna, Jablkowski Maciej, Kordek Radzislaw, Szemraj Janusz, Sliwinski Tomasz

Abstract excerpt

The molecular mechanism of hepatocellular carcinoma (HCC) is related to DNA damage caused by oxidative stress products induced by hepatitis B virus (HBV) or C (HCV) infection and exposure to environmental pollutants. Single-nucleotide polymorphisms (SNPs) of DNA damage response (DDR) genes may influence individual susceptibility to environmental risk factors and affect DNA repair efficacy, which, in turn, can...

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Source

Identifiers

PMID: 28598207
DOI: 10.1089/dna.2017.3664

Genes

APEX1
FEN1
LIG1
LIG3
MUTYH
PARP1
XRCC1
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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