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Article

Cognitive Normal Older Adults with APOE-2 Allele Show a Distinctive Functional Connectivity Pattern in Response to Cerebral Aβ Deposition.

International journal of molecular sciences - 8 Jul 2023

Wang Sheng-Min, Kang Dong Woo, Um Yoo Hyun, Kim Sunghwan, Kim Regina E Y, Kim Donghyeon, Lee Chang Uk, Lim Hyun Kook

Abstract excerpt

The ε2 allele of apolipoprotein E (ε2) has neuroprotective effects against beta-amyloid (Aβ) pathology in Alzheimer's disease (AD). However, its impact on the functional connectivity and hub efficiency in cognitively normal older adults (CN) with ε2 is unclear. We investigated the functional connectivity differences in the default mode network (DMN), salience network, and central executive network (CEN) between...

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Identifiers

PMID: 37511008
DOI: 10.3390/ijms241411250
PMCID: PMC10380008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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