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Article

Functional brain network centrality is related to APOE genotype in cognitively normal elderly.

Brain and behavior - 1 Sept 2018

Wink Alle Meije, Tijms Betty M, Ten Kate Mara, Raspor Eva, de Munck Jan C, Altena Ellemarije, Ecay-Torres Mirian, Clerigue Montserrat, Estanga Ainara, Garcia-Sebastian Maite, Izagirre Andrea, Martinez-Lage Alvarez Pablo, Villanua Jorge, Barkhof Frederik, Sanz-Arigita Ernesto

Abstract excerpt

INTRODUCTION: Amyloid plaque deposition in the brain is an early pathological change in Alzheimer's disease (AD), causing disrupted synaptic connections. Brain network disruptions in AD have been demonstrated with eigenvector centrality (EC), a measure that identifies central regions within networks. Carrying an apolipoprotein (APOE)-ε4 allele is a genetic risk for AD, associated with increased amyloid...

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Identifiers

PMID: 30136422
DOI: 10.1002/brb3.1080
PMCID: PMC6160659

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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