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Article

A longitudinal genome-wide association study of bone mineral density mean and variability in the UK Biobank.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Nov 2023

He Dan, Liu Huan, Wei Wenming, Zhao Yijing, Cai Qingqing, Shi Sirong, Chu Xiaoge, Qin Xiaoyue, Zhang Na, Xu Peng, Zhang Feng

Abstract excerpt

Bone mineral density (BMD) is an essential predictor of osteoporosis and fracture. We conducted a genome-wide trajectory analysis of BMD and analyzed the BMD change. PURPOSE: This study aimed to identify the genetic architecture and potential biomarkers of BMD. METHODS: Our analysis included 141,261 white participants from the UK Biobank with heel BMD phenotype data. We used a genome-wide trajectory analysis...

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PMID: 37500982
DOI: 10.1007/s00198-023-06852-1

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