Article
Multiple analyses of large-scale genome-wide association study highlight new risk pathways in lumbar spine bone mineral density.
Oncotarget - 24 May 2016
Wei Jinsong, Li Ming, Gao Feng, Zeng Rong, Liu Guiyou, Li Keshen
Abstract excerpt
Osteoporosis is a common human complex disease. It is mainly characterized by low bone mineral density (BMD) and low-trauma osteoporotic fractures (OF). Until now, a large proportion of heritability has yet to be explained. The existing large-scale genome-wide association studies (GWAS) provide strong support for the investigation of osteoporosis mechanisms using pathway analysis. Recent findings showed that...
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