Article
Effect of the English familial disease mutation (H6R) on the monomers and dimers of Aβ40 and Aβ42.
ACS chemical neuroscience - 20 Aug 2014
Viet Man Hoang, Nguyen Phuong H, Derreumaux Philippe, Li Mai Suan
Abstract excerpt
The self-assembly of the amyloid beta (Aβ) peptides into senile plaques is the hallmark of Alzheimer's disease. Recent experiments have shown that the English familial disease mutation (H6R) speeds up the fibril formation process of alloforms Aβ40 and Aβ42 peptides altering their toxicity to cells. We used all-atom molecular dynamics simulations at microsecond time scales with the OPLS-AA force field and TIP4P...
Topics
- Amyloid beta-Peptides
- Humans
- Hydrophobic and Hydrophilic Interactions
- Molecular Dynamics Simulation
- Mutation
- Peptide Fragments
- Protein Multimerization
- Protein Stability
- Protein Structure, Secondary
- Water