Article
The E46K mutation in alpha-synuclein increases amyloid fibril formation.
The Journal of biological chemistry - 4 Mar 2005
Greenbaum Eric A, Graves Charles L, Mishizen-Eberz Amanda J, Lupoli Michael A, Lynch David R, Englander S Walter, Axelsen Paul H, Giasson Benoit I
Abstract excerpt
The identification of a novel mutation (E46K) in one of the KTKEGV-type repeats in the amino-terminal region of alpha-synuclein suggests that this region and, more specifically, Glu residues in the repeats may be important in regulating the ability of alpha-synuclein to polymerize into amyloid fibrils. It was demonstrated that the E46K mutation increased the propensity of alpha-synuclein to fibrillize, but this...
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