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Article

Interaction of Mitochondrial Polygenic Score and Lifestyle Factors in LRRK2 p.Gly2019Ser Parkinsonism.

Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2023

Lüth Theresa, Gabbert Carolin, Koch Sebastian, König Inke R, Caliebe Amke, Laabs Björn-Hergen, Hentati Faycel, Sassi Samia Ben, Amouri Rim, Spielmann Malte, Klein Christine, Grünewald Anne, Farrer Matthew J, Trinh Joanne

Abstract excerpt

BACKGROUND: A mitochondrial polygenic score (MGS) is composed of genes related to mitochondrial function and found to be associated with Parkinson's disease (PD) risk. OBJECTIVE: To investigate the impact of the MGS and lifestyle/environment on age at onset (AAO) in LRRK2 p.Gly2019Ser parkinsonism (LRRK2-PD) and idiopathic PD (iPD). METHODS: We included N = 486 patients with LRRK2-PD and N = 9259 with iPD from...

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PMID: 37482924
DOI: 10.1002/mds.29563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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