Article

The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson’s disease

2023-08-25

Abstract excerpt

<h4>Objective</h4> To investigate the association between a Parkinson’s disease (PD)-specific polygenic score (PGS) and protective lifestyle factors on age at onset (AAO) in PD. <h4>Methods</h4> We included data from 4375 patients with idiopathic PD, 167 patients with GBA1 -PD, and 3091 healthy controls of European ancestry from AMP-PD, PPMI, and Fox Insight cohorts. The PGS was calculated based on a previously pr...

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Literature Corpus work: 2fac1489-2425-5dcb-a9ce-cc86c2d9713d
DOI: 10.1101/2023.08.25.23294466

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