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Article

Prediction of Parkinson's Disease Risk Based on Genetic Profile and Established Risk Factors.

Genes - 20 Aug 2021

Chairta Paraskevi P, Hadjisavvas Andreas, Georgiou Andrea N, Loizidou Maria A, Yiangou Kristia, Demetriou Christiana A, Christou Yiolanda P, Pantziaris Marios, Michailidou Kyriaki, Zamba-Papanicolaou Eleni

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder, and literature suggests that genetics and lifestyle/environmental factors may play a key role in the triggering of the disease. This study aimed to evaluate the predictive performance of a 12-Single Nucleotide Polymorphisms (SNPs) polygenic risk score (PRS) in combination with already established PD-environmental/lifestyle factors. METHODS:...

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Identifiers

PMID: 34440451
DOI: 10.3390/genes12081278
PMCID: PMC8393959

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