Article
Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank.
Journal of neurology, neurosurgery, and psychiatry - 1 Oct 2020
Jacobs Benjamin Meir, Belete Daniel, Bestwick Jonathan, Blauwendraat Cornelis, Bandres-Ciga Sara, Heilbron Karl, Dobson Ruth, Nalls Mike A, Singleton Andrew, Hardy John, Giovannoni Gavin, Lees Andrew John, Schrag Anette-Eleonore, Noyce Alastair J
Abstract excerpt
OBJECTIVE: To systematically investigate the association of environmental risk factors and prodromal features with incident Parkinson's disease (PD) diagnosis and the interaction of genetic risk with these factors. To evaluate whether existing risk prediction algorithms are improved by the inclusion of genetic risk scores. METHODS: We identified individuals with an incident diagnosis of PD (n=1276) and controls...
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