Article
Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions.
PloS one - 1 Jan 2024
Alektiar Jonathan M, Shan Mengrou, Radyk Megan D, Zhang Li, Halbrook Christopher J, Lin Lin, Espinoza Carlos, Mier Ivan F, Lavoie Brooke L, Salvatore Lucie, Pasca di Magliano Marina, Cantley Lewis C, Mueller Jacob L, Lyssiotis Costas A
Abstract excerpt
Malic Enzyme 1 (ME1) plays an integral role in fatty acid synthesis and cellular energetics through its production of NADPH and pyruvate. As such, it has been identified as a gene of interest in obesity, type 2 diabetes, and an array of epithelial cancers, with most work being performed in vitro. The current standard model for ME1 loss in vivo is the spontaneous Mod-1 null allele, which produces a canonically...
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